TITLE: Synthesis of High Specific Activity Tritium Labelled Compounds.

AUTHOR: P. Parent.

INST.  AUTHOR: CEA Centre d'Etudes Nucleaires de Saclay, Gif-sur-Yvette (France). Dept. de Biologie.

SPONSOR: Conservatoire National des Arts et Metiers (CNAM), 75 - Paris (France).

LANGUAGE: French

PUB.  TYPE: Technical Report

PUB.  COUNTRY: France

SOURCE: Department of Energy [DEE],  1986,  101p.

NTIS ORDER NO.: DE88756677/INW

ABSTRACT:

Tritiated methyl iodide of high specific activity is synthetized by Fischer-Tropsch reaction of tritium with carbon monoxide, tritiated methanol obtained is reacted with hydriodic acid. It is used for the synthesis of S-adenosyl L-methionine /sup 3/H-methyl and of diazepam /sup 3/H-methyl derivatives. Synthesis of 3-PPP/sup 3/H: (hydroxy-3 phenyl)-3N-n propyl (/sup 3/H-2.3) piperidine (/sup 3/H-2.3) with a specific activity of 4.25 T Bq/mM (115 Ci/mM) and of baclofene /sup 3/H with a specific activity of 0.925 TBq (25 Ci/mM) are also described. (ERA citation 14:013273)

REPORT  NUMBER: FRNC-TH-3375